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Publications
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W. Hwang,
S. L. Austin,
A. Blondel,
E. D. Boittier,
S. Boresch,
M. Buck,
J. Buckner,
A. Caflisch,
H.-T. Chang,
X. Cheng,
Y. K. Choi,
J,-W. Chu,
M. Crowley,
Q. Cui,
A. Damjanovic,
Y. Deng,
M. Devereux,
X. Ding,
M. Feig,
J. Gao,
D. R. Glowacki,
J. E. Gonzales II,
M. B, Hamaneh,
E. D. Harder,
R. L. Hayes,
J. Huang,
Y. Huang,
P. S. Hudson,
W. Im,
S. M. Islam,
W. Jiang,
M. R. Jones,
S. K&amul;ser,
F. L. Kearns,
N. R. Kern,
J. B. Klauda,
T. Lazaridis,
J. Lee,
J. A. Lemkul,
X. Liu,
Y. Luo,
A. D. MacKerell, Jr.,
D. T. Major,
M. Meuwly,
K. Nam,
L. Nilsson,
V. Ovchinnikov,
E. Paci,
S. Park,
R. W. Pastor,
A. R. Pittman,
C. B. Post,
S. Prasad,
J. Pu,
Y. Qi,
T. Rathinavelan,
D. R. Roe,
B. Roux,
C. N. Rowley,
J. Shen,
A. C. Simmonett,
A. J. Sodt,
K. T&omul;pfer,
M. Upadhyay,
A. van der Vaart,
L. I. Vazquez-Salazar,
R. M. Venable,
L. C. Warrensford,
H. L. Woodcock,
Y. Wu,
C. L. Brooks III,
B. R. Brooks,
M. Karplus,
"CHARMM at 45: Enhancements in accessibility, functionality, and speed"
J. Phys. Chem. B 128 (2024).
Access
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A. Akitsu, E. Kobayashi, Y. Feng, H. M. Stephens, K. N. Brazin, D. J. Masi, E. H. Kirpatrick, R. J. Mallis, J. S. Duke-Cohan, M. A. Booker, V. Cinella, W. W. Feng, E. L. Holliday, J. J. Lee, K. J. Zienkiewicz, M. Y. Tolstorukov, W. Hwang,
M. J. Lang, and E. L. Reinherz,
"Parsing digital or analogue TCR performance through piconewton forces,''
Sci. Adv. 10 eado4313 (2024).
Access
- A. C. Chang-Gonzalez, R. J. Mallis, M. J. Lang, E. L. Reinherz,
and W. Hwang, "Asymmetric framework motion of TCRαβ controls load-dependent peptide discrimination,''
eLife 14 e91881 (2024).
Access
- K. Tan, J. Chen, Y. Kak, Y. Wang, L. Donius, R. A. Khan, X. Li,
H. Richter, M. S. Seaman, T. Walz, W. Hwang, E. L. Reinherz, and M. Kim,
"Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility,''
Nat. Comm. 14 7218 (2023).
Access
- E. L. Reinherz, W. Hwang, and M. J. Lang, "Harnessing αβ T cell receptor mechanobiology to achieve
the promise of immunooncology"
Proc. Natl. Acad. Sci. USA 120 e2215694120 (2023).
Access
- J. Shi, J.-H. Cho, and W. Hwang, "Heterogeneous and allosteric role of surface hydration for protein-ligand binding"
J. Chem. Theory Comput. 19 1875-1887 (2023).
Access
Journal Cover
- J. S. Duke-Cohan, A. Akitsu, R. J. Mallis, C. M. Messier,
P. H. Lizotte, J. C. Aster, W. Hwang, M. J. Lang, and E. L. Reinherz,
"Pre-T cell receptor Self-MHC Sampling Restricts Thymocyte
Dedifferentiation,"
Nature 613 565-574 (2023).
Link
PDF
Nature News and Views
- A. C. Chang-Gonzalez, H. C. Gibbs, A. C. Lekven, A. T. Yeh,
and W. Hwang, "Building 3-Dimensional Model of Early-Stage Zebrafish
Embryo Brain,"
Biophys. Rep. 1 e100003 (2021).
Access
Journal Cover
- R. J. Mallis, J. S. Duke-Cohan, D. K. Das, A. Akitsu, A.
M. Luoma, D. Banik, H. M. Stephens, P. W. Tetteh, C. D. Castro, S.
Krahnke, R. E. Hussey, B. Lawney, K. N. Brazin, P. A. Reche, W. Hwang,
E. J. Adams, M. J. Lang, and E. L. Reinherz, "Molecular design of the
γδT cell receptor ectodomain encodes biologically fit ligand
recognition in the absence of mechanosensing,"
Proc. Natl. Acad. Sci. USA 118 e2023050118 (2021).
Access
- M. A. Herman, B. R. Aiello, J. D. DeLong, H. Garcia-Ruiz A. L.
González, W. Hwang, C. McBeth, E. A. Stojkovíc, M. A.
Trakselis and N. Yakoby, "A unifying framework for understanding
biological structures and functions across levels of biological
organization,"
J. Integ. Comparat. Biol. 61 2038-2047 (2021).
Link
PDF
- X. Li, R. Mizsei, K. Tan, R. J. Mallis, J. S. Duke-Cohan, A. Akitsu,
P. W. Tetteh, A. Dubey, W. Hwang, G. Wagner, M. J. Lang, H. Arthanari,
J.-H. Wang, and E. L. Reinherz,
"Pre-T cell receptors topologically sample self-ligands during the
β-selection phase of thymocyte development"
Science 371 181-185 (2021).
Link
PDF
- W. Hwang, R. J. Mallis, M. J. Lang, and E. L. Reinherz,
"The αβTCR mechanosensor exploits dynamic ectodomain allostery
to optimize its ligand recognition site"
Proc. Natl. Acad. Sci. USA 117 21336-21345 (2020).
Link
PDF
- J. Shi, Q. Shen, J.-H. Cho, and W. Hwang, "Entropy Hotspots for the Binding of Intrinsically Disordered Ligands to a Receptor Domain"
Biophys. J. 118 2502-2512 (2020).
Access
- J.-H. Cho, B. Zhao, J. Shi, N. Savage, Q. Shen, J. Byrnes, L. Yang, W. Hwang, and P. Li, "Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses"
Proc. Natl. Acad. Sci. USA 117 6550-6558 (2020).
Link
PDF
- W. Hwang and M. Karplus, "Structural Basis for Power Stroke vs. Brownian Ratchet Mechanisms of Motor Proteins"
Proc. Natl. Acad. Sci. USA 116 19777-19785 (2019).
Link
PDF
- R. J. Mallis, K. N. Brazin, J. S. Duke-Cohan, W. Hwang, J. Wang,
G. Wagner, H. Arthanari, M. J. Lang, and E. L. Reinherz,
"NMR: An Essential Structural Tool for Integrative Studies of T Cell Development, pMHC Ligand Recognition and TCR Mechanobiology"
J. Biomolec. NMR 73 319-332 (2019).
Link
PDF
- E. Eryilmaz, W. Teizer, and W. Hwang, "Macromolecular and nanoscale
investigation of intermolecular interactions driving the self-assembly of
collagen," Biomed. Phys. Eng. Express 5 045005 (2019).
Link
PDF
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B. Kang, S. Jo, J. Baek, F. Nakamura, W. Hwang, and H. Lee,
"Role of Mechanical Flow for Actin Network Organization"
Acta Biomater. 90 217--224 (2019).
Link
PDF
- X. Teng and W. Hwang, "Effect of methylation on local mechanics and hydration structure of DNA"
Biophys. J. 114 1791-1803 (2018).
Link
PDF
Journal Cover
- Q. Shen, J. Shi, D. Zeng, B. Zhao, P. Li, W. Hwang and J-H Cho,
"Molecular mechanisms of tight binding through fuzzy
interactions"
Biophys. J. 114 1313-1320 (2018).
Link
PDF
- W. Hwang, M. J. Lang, and M. Karplus, "Kinesin motility is driven by subdomain dynamics"
eLife 6 e28948 (2017).
Access
- D. N. Reinemann, E. G. Sturgill, D. K. Das, M. S. Degen, Z. Vörös,
W. Hwang, R. Ohi, and M. J. Lang, "Collective Force Regulation in
Anti-Parallel Microtubule Gliding by Dimeric Kif15 Kinesin Motors"
Curr.
Biol. 27 2810--2820 (2017).
Link
PDF
- H. C. Gibbs, A. C. Chang-Gonzalez, W. Hwang, A. T. Yeh, and
A. C. Lekven, "Midbrain-hindbrain boundary morphogenesis: At the intersection of Wnt and Fgf signaling"
Front. Neuroanat. 11 64 (2017).
Access
- E. Eryilmaz, W. Teizer, and W. Hwang, "In vitro analysis of
the co-assembly of type-I and type-III collagen"
Cell. Molec. Bioeng. 10 41-53 (2017).
Link
PDF
Journal Cover
- X. Teng and W. Hwang, "Elastic energy partitioning in DNA deformation
and binding to proteins"
ACS Nano 10 170-180 (2016).
Link
PDF
- K. Kim, A. Sikora, H. Nakazawa, M. Umetsu, W. Hwang, and W. Teizer,
"Isomorphic coalescence of aster cores formed in vitro from
microtubules and kinesin motors"
Phys. Biol. 13 056002 (2016).
Link
PDF
- A. Sikora, F. F. Canova, K. Kim, H. Nakazawa, M. Umetsu, I.\
Kumagai, T. Adschiri, W. Hwang, and W. Teizer, "Behavior of Kinesin
Driven Quantum Dots Trapped in a Microtubule Loop"
ACS Nano 9
11003-11013 (2015).
Link
PDF
- K. N. Brazin, R. J. Mallis, D. K. Das, Y. Feng, W.
Hwang, J.-H. Wang, G. Wagner, M. J. Lang and E. L. Reinherz,
"Structural features of the αβTCR mechanotransduction
apparatus that promote pMHC discrimination"
Front. Immunol.
6 441 (2015).
Access
- K. Kim, A. Sikora, K. S. Nakayama, M. Umetsu, W. Hwang and
W. Teizer, "Electric field-induced reversible trapping of microtubules
along metallic glass microwire electrodes"
J. Appl. Phys.
117 144701 (2015).
Link
PDF
- W. Hwang and E. Eryilmaz, "Kinetic signature of fractal-like filament networks formed by orientational linear epitaxy"
Phys. Rev. Lett. 113 025502 (2014).
Link
PDF
Journal Cover
- X. Teng and W. Hwang, "Chain Registry and Load-Dependent Conformational Dynamics of Collagen"
Biomacromolec. 15 3019-3029 (2014).
Link
PDF
- E. G. Sturgill, D. K. Das, Y. Takizawa, Y. Shin, S. Collier,
M. D. Ohi, W. Hwang, M. J. Lang and R. Ohi, "Kinesin-12 Kif15
targets kinetochore-fibers via an intrinsic two-step mechanism"
Curr. Biol. 24 2307-2313 (2014).
Access
- A. Sikora, J. Ramón-Azcón, K. Kim, K. Reaves, H. Nakazawa,
M. Umetsu, I. Kumagai, T. Adschiri, H. Shiku, T. Matsue, W.
Hwang and W. Teizer, "Molecular motor-powered shuttles along
multi-walled carbon nanotube tracks"
Nano Lett. 14
876-881 (2014).
Link
PDF
- K. Kim, A. Sikora, K. S. Nakayama, H. Nakazawa, M. Umetsu,
W. Hwang, and W. Teizer, "Functional localization of
kinesin/microtubule-based motility system along 2 metallic glass
microwires"
Appl. Phys. Lett. 105 143701 (2014).
Link
PDF
- K. Kim, A. Liao, A. Sikora, D. Oliveira, H. Nakazawa, M. Umetsu,
I. Kumagai, T. Adschiri, W. Hwang, and W. Teizer, "Microtubule
shuttles on kinesin-coated glass micro-wire tracks"
Biomed.
Microdev. 16 501-508 (2014).
Link
PDF
- N. Varongchayakul, S. Johnson, T. Quabili, J. Cappello,
H. Ghandehari, S. Solares, W. Hwang, and J. Seog, "Direct
observation of amyloid nucleation under nanomechanical stretching"
ACS Nano 7 7734-7743 (2013).
Link
PDF
- W. R. Hesse, M. Steiner, M. L. Wohlever, R. D. Kamm, W. Hwang, and M. J. Lang, "Modular Aspects of Kinesin Force Generation Machinery"
Biophys.
J. 104 1969-1978 (2013).
Link
PDF
- W. Hwang and M. J. Lang, "Nucleotide-Dependent Control of Internal Strains in Ring-Shaped AAA+ Motors"
Cell. Molec. Bioeng. 6
65-73 (2013).
Link
PDF
- A. Sikora, D. Oliveira, K. Kim, A. L. Liao, M. Umetsu, I. Kumagai, T. Adschiri, W. Hwang and W. Teizer,
"Quantum Dot Motion on Microtubules"
Chem. Lett. 41
1215-1217 (2012).
Link
PDF
- K. M. Ravikumar and W. Hwang, "Role of Hydration Force in the
Self-Assembly of Collagens and Amyloid Steric Zipper Filaments"
J.
Am. Chem. Soc. 133 11766-11773 (2011)
Link
PDF
- S. K. Lakkaraju and W. Hwang, "Hysteresis-based mechanism
for the directed motility of the Ncd motor"
Biophys. J. 101
1105-1113 (2011).
Access
- W. Leow and W. Hwang, "Epitaxially Guided Assembly of Collagen Layers on Mica Surfaces"
Langmuir 27 10907-10913 (2011).
Link
PDF
- T. Kim, W. Hwang, and R. D. Kamm, "Dynamic Role of
Cross-linking Proteins in Actin Rheology"
Biophys. J. 101
1597-1603 (2011).
Access
- J. M. Hirshburg, K. M. Ravikumar, W. Hwang and A. T. Yeh,
"Molecular basis for optical clearing of collagenous tissues"
J.
Biomed. Optics 15, 055002 (2010).
Access
- G. Bao, R. D. Kamm, W. Thomas, W. Hwang, D. A. Fletcher,
A. Grodzinsky, C. Zhu, and M, R. K. Mofrad, "Molecular Biomechanics:
The Molecular Basis of How Forces Regulate Cellular Function"
Cell. Molec. Bioeng. 3 91-105 (2010).
Link
PDF
- M. J. Lang and W. Hwang, "Motor Proteins: Kinesin Drives
with an Underhead Cam"
Curr. Biol. 20 R408-R410 (2010).
Access
- S. K. Lakkaraju and W. Hwang, "Critical buckling length versus
persistence length: What governs biofilament conformation?"
Phys. Rev. Lett. 102 118102 (2009).
Link
PDF
- J. Park, B. Kahng, and W. Hwang, "Thermodynamic selection of
steric zipper patterns in the amyloid cross-β spine"
PLoS
Comp. Biol. 5 e1000492 (2009).
Access
- J. A. Noel, W. Teizer, and W. Hwang, "Surface
manipulation of microtubules using self-assembled monolayers and
electrophoresis"
ACS Nano 3 1938-1946 (2009).
Link
PDF
- J. A. Noel, W. Teizer, and W. Hwang, "Antifouling
self-assembled monolayers on microelectrodes for patterning
biomolecules"
J. Visualized Exp. 30 doi:10.3791/1390 (2009).
Access
- T. Kim, W. Hwang, H. Lee, and R. D. Kamm, "Computational
analysis of viscoelastic properties of crosslinked actin networks"
PLoS Comp. Biol. 5 e1000439 (2009).
Access
- W. Hwang and M. J. Lang, "Mechanical design of translocating
motor proteins"
Cell Biochem. Biophys. 54 11-22 (2009)
Link
PDF
- M.-E. Aubin-Tam, W. Hwang, and K. Hamad-Schifferli, "Site-directed
nanoparticle labeling of cytochrome c"
Proc. Natl. Acad. Sci. USA
106 4095-4100 (2009).
Access
- S. K. Lakkaraju and W. Hwang, "Modulation of elasticity in
functionally distinct domains of the tropomyosin coiled-coil"
Cell. Molec. Bioeng. 2 57-65 (2009).
Link
PDF
- T. Kim, W. Hwang, and R. D. Kamm, "Computational analysis of
a cross-linked actin-like network"
Exp. Mech. 49 91-104
(2009).
Link
PDF
- F. Taraballi, M. Campione, A. Sassella, A. L. Vescovi, A.
Paleari, W. Hwang, and F. Gelain, "Effect of functionalization
on the self-assembling propensity of β-sheet forming peptides"
Soft Matter 5 660-668 (2009).
Link
PDF
- A. S. Khalil, D. C. Appleyard, A. K. Labno,
A. Georges, M. Karplus, A. M. Belcher, W. Hwang, and M. J.
Lang, "Kinesin's cover-neck bundle folds forward to generate force"
Proc. Natl. Acad. Sci. USA 105 19247-19252 (2008).
Access
- K. M. Ravikumar and W. Hwang, "Region-specific role of water in
collagen unwinding and assembly"
Proteins: Struct. Func. Bioinf.
72 1320-1332 (2008).
Link
PDF
- W. Hwang, M. J. Lang, and M. Karplus, "Force generation in
kinesin hinges on cover-neck bundle formation"
Structure
16 62-71 (2008).
Access
Journal Cover
- W. Hwang, "Calculation of conformation-dependent biomolecular
forces"
J. Chem. Phys. 127 175104 (2007).
Link
PDF
- K. M. Ravikumar, J. D. Humphrey, and W. Hwang, "Spontaneous
unwinding of a labile domain in a collagen triple helix"
J. Mech. Mater. Struct. 2 999-1010 (2007).
Access
- J. Park, B. Kahng, R. D. Kamm, and W. Hwang, "Atomistic
simulation approach to a continuum description of self-assembled
β-sheet filaments"
Biophys. J. 90
2510-2524 (2006).
Access
- A. Lomander, W. Hwang, and S. Zhang,
"Hierarchical self-assembly of a coiled-coil peptide into fractal structure"
Nano. Lett. 5 1255-1260 (2005).
Link
PDF
- W. Hwang, S. Zhang, R. D. Kamm, and M. Karplus,
"Kinetic control of dimer structure formation in amyloid
fibrillogenesis"
Proc. Natl. Acad. Sci. USA 101
12916-12921 (2004).
Access
- J. R. Lu, S. Perumal, I. Hopkinson, J. R. P. Webster,
J. Penfold, W. Hwang, and S. Zhang,
"Interfacial nano-structuring of designed peptides regulated by
solution pH"
J. Am. Chem. Soc. 126 8940-8947 (2004).
Link
PDF
- W. Hwang, D. M. Marini, R. D. Kamm, and S. Zhang,
"Supramolecular Structure of Helical Ribbons Self-Assembled from a
β-Sheet Peptide"
J. Chem. Phys. 118 389-397 (2003).
Link
PDF
- S. Zhang, D. M. Marini, W. Hwang, and S. Santoso,
"Design of Nano Biological Materials through Self-Assembly of
Peptides and Proteins"
Curr. Opin. Chem. Biol.
6 865-871 (2002).
Link
PDF
- S. Santoso, W. Hwang, W. Hartman, and S. Zhang,
"Self-assembly of Surfactant-like Peptides with Variable Glycine Tails
to Form Nanotubes and Nanovesicles"
Nano Lett. 2, 687-691 (2002).
Link
PDF
- D. M. Marini, W. Hwang, S. Zhang, D. A. Lauffenburger, and R.
D. Kamm, "Left-Handed Helical Ribbon Intermediates in the
Self-Assembly of a β-Sheet Peptide"
Nano Lett.
2, 295-299 (2002).
Link
PDF
- W. Hwang, P. Krapivsky, and S. Redner
"Fitness versus Longevity in Age-Structured Population Dynamics"
J. Math. Biol. 44, 375-393 (2002).
Link
PDF
- W. Hwang and S. Redner, "Dissolution in a Field"
Phys. Rev. E 64, 041606 (2001).
Link
PDF
- W. Hwang and S. Redner, "Infiltration Through Porous Media"
Phys. Rev. E 63, 021508 (2001).
Link
PDF
- W. Hwang, P. Krapivsky and S. Redner,
"Does Good Mutation Help You Live Longer?"
Phys. Rev. Lett. 83, 1251-1254 (1999).
Link
PDF
- S. Kwon, W. Hwang, and H. Park
"Dynamic Behavior of Driven Interfaces in Models with Two Absorbing
States"
Phys. Rev. E 59, 4949-4952 (1999).
Link
PDF
- W. Hwang and H. Park
"Interacting Monomer-Dimer Model with Infinitely Many Absorbing States"
Phys. Rev. E 59, 4683-4686 (1999).
Link
PDF
- W. Hwang, S. Kwon, H. Park, and H. Park "Critical Phenomena of
Nonequilibrium Dynamical Systems with Two Absorbing States"
Phys. Rev. E 57, 6438-6450 (1998).
Link
PDF